Welcome to Vitalopedia

A place for health & longevity optimization. Discover the latest clinical research on supplements, diets, therapies, foods & more alongside curated protocols to achieve your goals. Read more about Vitalopedia.

Protocols

Curated guides to help you act on the science.

Generate your Personal Protocol
Bryan Johnson's Blueprint Protocol
Bryan Johnson's Blueprint Protocol
Expert Protocol
Brain Health Foundations
Brain Health Foundations
Expert Protocol
Increase your energy levels
Increase your energy levels
Expert Protocol
Longevity Protocol
Longevity Protocol
Expert Protocol
Sleep Protocol (Huberman)
Sleep Protocol (Huberman)
Expert Protocol

Top Recommendations

Top-scored tools and ingredients from the library.

Recent Studies

Newly added peer-reviewed research and clinical analyses.

Efficacy and safety of low-molecular-weight collagen peptides in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial
Frontiers in Nutrition • 2025
Targeted Use
RCT (Double-blind)
n=80
⚠ COI
"This randomized, double-blind, placebo-controlled trial demonstrated that daily supplementation with 3,000 mg of low-molecular-weight collagen peptides (LMCP) for 180 days significantly reduced knee pain and improved physical function in adults with mild knee osteoarthritis (Kellgren-Lawrence grade I or II). The study found no adverse effects and concluded that LMCP is a safe and effective non-pharmacological option for managing joint pain in this specific population."
Source
Clinical and Salivary Antioxidant Effects of Matcha Tea in Patients with Gingivitis: A Randomized Controlled Trial
The Open Dentistry Journal • 2025
Targeted Use
RCT (Single-blind)
n=41
"The study proved that daily consumption of two cups of Matcha tea for 30 days significantly improves salivary antioxidant profiles by reducing malondialdehyde (a marker of lipid peroxidation) and increasing levels of antioxidant enzymes like superoxide dismutase and glutathione peroxidase 1. However, these biochemical benefits did not result in statistically significant clinical improvements in plaque or gingival inflammation beyond what was achieved through standard oral hygiene practices alone."
Source
Acupuncture for Chronic Low Back Pain in Older Adults: A Randomized Clinical Trial
JAMA Network Open • 2025
Targeted Use
RCT (Single-blind)
n=800
"This randomized clinical trial found that acupuncture, whether provided as a standard 12-week course or with additional maintenance sessions, significantly improved disability and pain intensity in older adults with chronic low back pain compared to usual medical care alone. These benefits were sustained through 12 months of follow-up, and the treatment was found to be safe and well-tolerated."
Source
Multimodal AI correlates of glucose spikes in people with normal glucose regulation, pre-diabetes and type 2 diabetes
Nature Medicine • 2025
Indeterminate
Cohort Study
n=2416
"This study demonstrated that multimodal AI-driven glycemic risk profiles—which integrate data from the gut microbiome, resting heart rate, and continuous glucose monitoring—are significantly more informative than traditional HbA1c tests for risk stratification. It proved that these profiles can identify high-risk individuals among those with normal glucose levels and showed significant correlations between glucose spike resolution and resting heart rate, potentially improving early prevention and diagnosis of Type 2 diabetes."
Source
Effects of Moringa oleifera supplementation on immune and nutritional biomarkers in adults living with HIV: a systematic review and meta-analysis
Frontiers in Nutrition • 2025
Targeted Use
Meta-analysis
"A meta-analysis of 7 articles revealed that Moringa supplementation significantly increased CD4+ T cell counts, white blood cells, platelets, and BMI in individuals living with HIV."
Source
Clinical Benefits of Exogenous Ketosis in Adults with Disease: A Systematic Review
Nutrients • 2025
Targeted Use
Systematic Review
"This systematic review of 51 studies found that exogenous ketosis shows therapeutic potential for neurological, metabolic, and cardiovascular disorders, with ketone esters appearing more effective than salts."
Source

Recent Videos

Recent explainers and discussions from the channel archive.

What is Healthy Longevity?

Healthy Longevity is the proactive practice of optimizing your healthspan—the number of years lived in peak physical and cognitive condition—rather than just extending your lifespan.

Definition

The 4 Pillars of Health & Longevity

Build your protocol around nutrition, targeted support, movement, and recovery.

1

Foods & Supplements

Prioritize nutrient-dense whole foods to support metabolic health, reduce inflammation, and provide the foundation for long-term vitality. Use evidence-based supplementation to correct deficiencies.

2

Exercise

Exercise is medicine for longevity. Combine resistance training to preserve muscle mass, cardiovascular work to support heart health, and mobility exercises to maintain function and independence.

3

Sleep

Protect consistent, high-quality sleep to optimize recovery, hormone regulation, cognitive performance, and healthy aging.

4

Early detection

Early detection of health issues through regular screenings and biomarker monitoring allows for timely interventions that can prevent disease progression and support longevity.

Bridging Science and Longevity

Trust

Peer-Reviewed Sources

Every recommendation is backed by published clinical evidence.

Expert

Driven Analysis

Insights from leading Harvard, Stanford, and Mayo Clinic researchers.

Up to date

Real-time Updates

Continuous monitoring of the latest studies and expert consensus.