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Spermidine

Updated 3/10/2026
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Research Summary

Spermidine is a naturally occurring polyamine compound that plays a vital role in cellular growth, DNA stability, and overall cell survival. Originally discovered in human semen (giving it its name), it is now known to exist in every cell of the human body and is found in high concentrations in foods such as wheat germ, soybeans, mushrooms, and aged cheeses. As we age, natural levels of spermidine in our tissues and blood decline significantly, which is why scientists have identified it as a key 'geroprotector' or anti-aging molecule. Supplementation is primarily used to restore these levels and support cellular renewal through 'cleanup' processes that become less efficient over time.

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