Rapamycin

Rapamycin, also known as Sirolimus, is a powerful macrolide compound originally discovered in the soil of Easter Island (Rapa Nui). While initially classified as an antifungal, it is FDA-approved as a prescription immunosuppressant to prevent organ transplant rejection and to treat a rare lung disease called lymphangioleiomyomatosis (LAM). In the field of geroscience, Rapamycin is considered the most robust pharmacological candidate for extending lifespan and healthspan, having consistently increased the lives of every animal species tested, including yeast, worms, flies, and mice. It is currently the focus of intense research for its potential to delay age-related decline in humans.